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Synthesis of LY294002-loaded PDLLA-PEG nanoparticles (GEM-Chit NPs) with flash nanoprecipitation. Two streams undergo turbulent mixing within the mixing chamber, forming the core of the nanoparticles. The nanoparticles are predicted to exhibit a core–shell structure with the IP:LY salt forming the nanoparticle core and the PDLLA-PEG forming a stabilizing corona.
