Table 3.
B7-H3-targeting CAR-T cells in preclinical studies involving extracranial PSTs.
| Study (Reference) |
Agent/Drug | Study Models |
|---|---|---|
| Majzner et al. [4] |
B7-H3 CAR-T cells | - Orthotopic xenograft models of ES and OS - Metastatic OS xenograft model |
| Talbot et al. [17] |
B7-H3 CAR-T cells | - In vitro OS model - Orthotopic spontaneously metastasizing OS xenograft model |
| Nguyen et al. [120] |
B7-H3 CAR-T cells | - In vitro OS model - Locoregional OS xenograft model - Systemic OS xenograft model |
| Zhang et. al. [45] |
B7-H3 CAR-T cells | - In vitro OS model - Patient-derived xenograft model of OS |
| Birley et al. [121] |
B7-H3 CAR-T cells | - In vitro NB model - In vivo NB model |
| Du et al. [44] |
B7-H3 CAR-T cells | - In vitro NB model - Metastatic NB xenograft model |
| Moghimi et al. [122] |
GD2-B7-H3 CAR-T cells | - In vitro NB model - Metastatic NB xenograft model |
| Tian et al. [123] |
BiCis GPC2/B7-H3 CAR-T cells | - In vitro NB model - Patient-derived xenograft model of NB |
| Grote et al. [46] |
B7-H3 CAR-NK-92 | - In vitro NB model - Three-dimensional NB spheroid model |
Abbreviations: B7-H3: B7 homolog 3; CAR: chimeric antigen receptor; PSTs: pediatric solid tumors; ES: Ewing sarcoma; OS: osteosarcoma; NB: neuroblastoma; GD2: disialoganglioside; BiCis: bicistronic; GPC2: glypican 2; NK: natural killer.