Table 4.

B7-H3-targeting CAR-T cells in clinical studies involving PSTs. The table shows the studies on extracranial PSTs as well as the studies involving their metastases in CNS.

Study/Phase (Reference)	Agent/Drug	Study Participants	Status
NCT05562024 Phase I [124]	B7-H3 CAR-T cells TAA06	Patients with relapsed/refractory NB	Recruiting
NCT04897321 Phase I [125]	B7-H3 CAR-T cells	Patients with OS, RMS, ES, NB, WT, DSRCT, and other B7-H3-expressing PSTs	Recruiting
NCT04483778 Phase I [126]	41BBζ B7-H3-EGFRt-DHFR CAR-T cells	Children and young adults with relapsed or refractory non-CNS solid tumors	Recruiting
NCT04637503 Phase I/II [127]	4SCAR-T cells targeting GD2, PSMA and B7-H3	Patients with relapsed/refractory NB	Recruiting
NCT04864821 Early Phase I [128]	B7-H3 CAR-T cells	Patients with NB and OS	Not yet recruiting
NCT04432649 Phase I/II [129]	4SCAR-T cells targeting B7-H3	Patients with refractory and/or recurrent solid tumors	Recruiting

Abbreviations: B7-H3: B7 homolog 3; CAR: chimeric antigen receptor; PSTs: pediatric solid tumors; CNS: central nervous system; NB: neuroblastoma; OS: osteosarcoma; RMS: rhabdomyosarcoma; ES: Ewing sarcoma; WT: Wilms tumor; DSRCT desmoplastic small round cell tumor; EGFRt: truncated epidermal growth factor receptor; DHFR: dihydrofolate reductase; 4SCAR: fourth-generation CAR.