Table 6.

Natural Products sensitizing Drug Resistance.

Classification	Compound/Extract	Source	Cell Line/Animal Model	Dose; Duration	Efficacy	Mechanism	Ref.
polyphenols	Resveratrol (RES)	peanuts, mulberries, peel of grapes	pumc-91/ADM	10, 50, 100 µM; 48 h	Reversion of drug resistance	↑Topo-II ↓MRP1, LRP, GST, BCL-2	[81]

Footer: pumc-91/ADM, adriamycin (ADM)-resistant pumc-91 cells; ↑, up-regulation; Topo-II, topoisomerase II; ↓, down-regulation; MRP1, multi-drug resistance 1; LRP, lung resistance protein; GST, glutathione S-transferase; BCL-2, B-cell leukemia/lymphoma 2.