Table 1.

Significantly different individual metabolites in the BALF.

Comparison	Change	Metabolite	p Value	Fold Change
Menopause vs. Control	Downregulated	TMAO	0.007	0.11
		2-HydroxybenzoicAcid	0.012	0.30
		Threonine	0.014	0.59
		Homoserine	0.016	0.60
		Hippuric Acid	0.038	0.46
		Hydroxyproline	0.046	0.63
		5-Aminolevulinic Acid	0.049	0.67
	Upregulated	4-Aminobutyric Acid	0.080	5.42
HDM vs. Control	Downregulated	Fructose	0.041	0.60
		Ribose	0.045	0.61
		TMAO	0.048	0.25
	Upregulated	9-Octadecynoic Acid	0.001	3.31
		Acetamide	0.005	1.55
		Glycocyamine	0.012	2.15
Menopause HDM vs. Menopause	Upregulated	Cytosine	0.0003	3.96
		GlycoCyamine	0.005	1.92
		9-Octadecynoic Acid	0.011	2.24
		D-Ribose 5-phosphate	0.013	2.98
		Cytidine	0.023	2.21
		Phenylpyruvic Acid	0.040	1.86
Menopause HDM vs. HDM	Upregulated	Cytosine	0.00005	2.17
		Cytidine	0.015	2.05
		Glutamic Acid	0.033	2.44
		D-Ribose 5 Phosphate	0.047	1.96

Statistical significance acquired using t-test with a p-value cutoff of 0.05 and a fold change cutoff of 1.5. Italicized metabolites did not reach statistical significance of p ≤ 0.05 but were of particular interest.