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. 2023 Apr 18;16(4):607. doi: 10.3390/ph16040607

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A–D): In the top 50 drugs of the four different approaches, we showed the intersection of each with genes associated with sarcopenia ((A): Lincs algorithm; (B): Gene2drug algorithm; (C): Pathway2drug algorithm; (D): Crank algorithm). There is no display of drugs that do not interact with sarcopenia-associated genes. (E): The UPSet plot shows the intersections of the drugs/small molecules from the four rank lists that have intersected with the sarcopenia-associated genes. (F): PPI network of the vorinostat-associated genes. (G): Gene Ontology (biological process) enrichment analysis for the 25 genes that are included in the PPI network of vorinostat.