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. 2023 Apr 5;15(4):1148. doi: 10.3390/pharmaceutics15041148

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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KAN0441571C inhibited migration of lung cancer cell lines in the scratch wound healing assay. (A) Migration of A549 was inhibited as shown by images acquired after 0, 24, and 48 h of incubation with different concentrations of KAN0441571C. Images of 1 representative experiment out of 4 for each cell line is shown. (B) Rate of wound closure (relative wound density) of lung cancer cells. The Incucyte Zoom Imager Software Analyzer was used to count the number of lung cancer cells during 48 h of incubation with of KAN0441571C (25–1000 nM). DMSO used as control. (C) Reduction (mean ± SEM) of cell migration (RWD AUC) after treatment with KAN0441571C (0–1000 nM) in 4 cell lines. **** p < 0.0001.