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Combination index (CI) plots for apoptosis (Annexin V/PI) in lung cancer cell lines incubated (24 h) with a combination of KAN0441571C (250 nM) with ibrutinib (571Ibr) (blue symbols) or erlotinib (571Erl) (red symbols) (5000–10,000 nM, see Figure 6). Values across Fa in lung cancer cells are shown, where Fa is the % of cell death. CI < 1 synergistic effect; CI = 1 additive effect; CI > 1 antagonistic effect (Chou–Talalay method).
