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. 2023 Mar 26;15(4):1069. doi: 10.3390/pharmaceutics15041069

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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Drug concentration profiles (dissolved, (A)), total amount profiles (dissolved and undissolved/precipitate, (B)), and undissolved/precipitated amount (C) obtained from the aqueous filtered and un-filtered phase; partitioning profiles ((D1) concentration/time vs. (D2) mass/time) obtained from the organic phase during in vitro DTPS experiments using VR of 0.4 vs. 0.8 and 75 mg IR tablet formulation. The precipitated mass/amount (Equations (1) and (4)) must be considered as solid mass/amount consisting of undissolved and precipitated API. Means ± SD, n = 3.

Drug concentration profiles (dissolved, (A)), total amount profiles (dissolved and undissolved/precipitate, (B)), and undissolved/precipitated amount (C) obtained from the aqueous filtered and un-filtered phase; partitioning profiles ((D1) concentration/time vs. (D2) mass/time) obtained from the organic phase during in vitro DTPS experiments using VR of 0.4 vs. 0.8 and 75 mg IR tablet formulation. The precipitated mass/amount (Equations (1) and (4)) must be considered as solid mass/amount consisting of undissolved and precipitated API. Means ± SD, n = 3.