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. 2023 Mar 26;15(4):1069. doi: 10.3390/pharmaceutics15041069

Figure 4.

Figure 4

Figure 4

Drug concentration profiles (dissolved, (A)), total amount profiles (dissolved and undissolved/precipitate, (B)), and undissolved/precipitated amount (C) obtained from the aqueous filtered and un-filtered phase; partitioning profiles ((D1) concentration/time vs. (D2) mass/time) obtained from the organic phase during in vitro DTPS experiments using VR of 0.8 at simulated gastric emptying rates of 5 min half-time vs. 9 min half-time and 75 mg IR tablet formulation. The precipitated mass/amount (Equations (1) and (4)) must be considered as solid mass/amount consisting of undissolved and precipitated API. Means ± SD, n =3.