Table 4.
Comparison of area under the plasma concentration-time curve vs. area under the concentration-time curve obtained from in vitro transfer model experiments vs. area under the concentration-time curve of the aqueous dissolved amount and the organic partitioned amount obtained from in vitro DTPS experiments. Clinical data represent means (n = 12 for 75 mg, and n = 6 for 200 and 500 mg).
| AUC0–120min (µg/mL × h) | OS 75 mg | OS 200 mg | OS 500 mg | OS 200 mg/ OS 75 mg |
OS 500 mg/ OS 200 mg |
OS 500 mg/ OS 75 mg |
|---|---|---|---|---|---|---|
| Transfer model data | 179.8 ± 18.1 | 114.4 ± 3.5 | 111.8 ± 1.5 | 0.63 | 0.98 | 0.62 |
| DTPS data aqueous | 85.1 ± 2.1 | 106.6 ± 7.4 | 133.3 ± 2.6 | 1.25 | 1.25 | 1.57 |
| DTPS data organic | 188.1 ± 4.4 | 579.21 ± 23.0 | 1492.5 ± 76.3 | 2.46 | 2.58 | 7.93 |
| Plasma data | 0.31 | 0.625 | 2.059 | 2.02 | 3.29 | 6.64 |