. 2023 Apr 20;13(4):694. doi: 10.3390/jpm13040694

Table 4.

Selected ongoing clinical trials in CTCs and solid tumors.

Malignancy	Trial Name	NCT Number	Patients	Study Arm	Control Arm	Primary Outcome
CRC	POACC-1	03700411	Undergoing open radical surgery for CRC	Morphine	N/A	Change in CTCs count following surgery depending on the type of perioperative analgesia
				Piritramid
				Epidural
Breast	HER2Cell	04993014	Early HER2+ breast cancer w/complete response to neoadjuvant trastuzumab and pertuzumab	Adjuvant trastuzumab	N/A	DFS between adjuvant arms based on whether the patient had HER2 + CTCs at baseline analysis
Breast	HER2Cell	04993014		Adjuvant trastuzumab plus pertuzumab	N/A
Liver	N/A	04800497	Resected HCC	N/A	N/A	Association between CTCs obtained 0, 30, 90, 180, and 365 days following surgical resection and DFS
Breast	N/A	03928210	Advanced or metastatic breast cancer	Digoxin	N/A	Change in CTCs cluster size after ingestion of oral digoxin
Breast	N/A	04065321	Luminal A breast cancer w/o lymph node involvement	CTCs monitoring	PET-CT examination	DFS
Prostate	C-ProMeta-1	05533515	Localized prostate cancer scheduled for robot-assisted prostatectomy	CTCs level prior to surgery and at 3 months post-surgery	N/A	Post-radical prostatectomy treatment failure during 4.5 years of follow-up
Thoracic malignancy	N/A	04048512	Neoplastic thoracic disease undergoing resection with intraoperative ECMO or CPB	CTCs quantification	N/A	Quantification of CTCs before and after surgery
Thoracic malignancy	N/A	04048512	Neoplastic thoracic disease undergoing resection without ECMO or CPB	CTCs quantification	N/A	Quantification of CTCs before and after surgery
Pancreas	EUS-CTCs	04677244	Suspected pancreas cancer	CTCs detection in portal venous blood before and after endoscopic biopsy	N/A	Frequency of increase of CTCs > 4cells/mL in portal system after endoscopic biopsy
Bladder	N/A	04811846	Recurrent transitional cell cancer of the bladder	Transurethral resection of bladder tumor	N/A	Change of CTC count in blood before, during, and after the procedure, and CTC number and characterization in purging fluid
Bladder	N/A	04811846	Recurrent transitional cell cancer of the bladder	Plasma kinetic vaporization of bladder tumor	N/A
Stomach	N/A	05208372	Gastric cancer	Radical laparotomy	N/A	Quantity and classification of CTCs in ascites and blood and expression of ctDNA in ascites and blood
Stomach	N/A	05208372	Gastric cancer	Laparoscope-assisted radical gastrectomy	N/A

Abbreviations: CRC: colorectal cancer, CTCs: circulating tumor cell, DFS: disease-free survival, ECMO: extracorporeal membrane oxygenation, CPB: cardiopulmonary bypass.