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. 2023 Apr 12;28(8):3386. doi: 10.3390/molecules28083386

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© 2023 by the authors.

Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).

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(A) Immunohistochemical staining of tyrosine hydroxylase (TH). The MPTP group exhibited dopamine deficiency syndrome. Co-treatment of HEM ameliorated MPTP-reduced TH expression in a dose-dependent manner. (B) The positive area of striatum is expressed in a Box and Whisker Plot. The results reflect the mean values of cells. The letter “a” represents a statistical difference (p < 0.01) compared to the control group, while the letter “b” represents a statistical difference (p < 0.01) compared to the MPTP treatment group. The statistical analysis was performed using Holm-Sidak tests.