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. 2023 May 1;133(9):e160451. doi: 10.1172/JCI160451

Figure 2. The endothelial glycocalyx is disrupted in psoriatic skin vessels.

Figure 2

(A) Network visualization of pathways enriched in psoriatic capillary ECs compared with healthy capillary ECs. Network nodes, which are colored by adjusted P value and sized by rich factor, represent individual enriched gene sets; edges represent shared genes between nodes. (B and C) TEM and SEM showing the endothelial glycocalyx in skin blood vessels from healthy individuals and psoriasis patients (n = 3 skin samples/group). The endothelial glycocalyx is highlighted by the yellow dotted line. (D and E) Average endothelial glycocalyx thickness and coverage in skin vessels of healthy individuals and psoriasis patients (n = 9 vessels of 3 skin samples/group). (F and G) Immunofluorescence and MFI quantification of HA on skin ECs from healthy subjects and psoriasis patients (n = 21 vessels of 7 skin samples/group). (H and I) Immunofluorescence and MFI quantification of HS on skin ECs from healthy subjects and psoriasis patients (n = 21 vessels of 7 skin samples/group). Data are represented as mean ± SD. Analysis was performed using unpaired Student’s t test.