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. 2023 Apr 26;7(5):e0138. doi: 10.1097/HC9.0000000000000138

FIGURE 3.

FIGURE 3

Ethanol suppresses bile acid synthesis and reduces the bile acid pool in Tgr5 −/− mice. Bile acids (BA) were quantified in (A) Serum, (B) Liver, (C) Intestine, and (D) Gallbladder. (E) Gallbladder volume. (F) Fecal bile acids. (G) Bile acid pool, summed from total liver, intestine, and gallbladder bile acids. (H and I) Hepatic expression of genes involved in bile acid synthesis and transport. (J) Ileum and colon expression of genes involved in bile acid regulation and transport. *p < 0.05, **p < 0.01, ***p < 0.001. n = 5–6. Abbreviations: Ctl, control diet + maltose binge; EtOH, ethanol diet + ethanol binge; WT, wild type.