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. 2023 Apr 26;7(5):e0138. doi: 10.1097/HC9.0000000000000138

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Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/

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Leptin metabolism is altered in Tgr5 ^−/− mice fed ethanol. (A) Serum leptin. (B) mRNA expression of leptin in WAT. (C) mRNA expression of leptin receptor in liver. (D) Expression of lipogenic and lipolytic genes in WAT. (E) Expression of browning genes in WAT. (F) Expression of genes involved in glucose regulation in WAT. (G) Expression of Fgf21 and regulatory genes in WAT. *p < 0.05, **p < 0.01, ***p < 0.001. n = 5–6. Abbreviations: Ctl, control diet + maltose binge; EtOH, ethanol diet + ethanol binge; WAT, white adipose tissue; WT, wild type.