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. 2023 Apr 26;7(5):e0138. doi: 10.1097/HC9.0000000000000138

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Copyright © 2023 The Author(s). Published by Wolters Kluwer Health, Inc. on behalf of the American Association for the Study of Liver Diseases.

This is an open access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal. http://creativecommons.org/licenses/by-nc-nd/4.0/

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Ethanol-induced Fgf21 in Tgr5 ^−/− mice. Chronic + binge ethanol typically induces steatosis and liver damage. In Tgr5 ^−/− mice, ethanol increased Fgf21, which exerts metabolic effects in the liver, adipose tissue, and elsewhere and is implicated in mediating preference for ethanol and carbohydrate consumption. This may contribute to Fgf21-induced alterations in leptin sensitivity and downstream leptin signaling in Tgr5 ^−/− mice. Figure created with Biorender.com. Abbreviations: EtOH, ethanol diet + ethanol binge; FFA, free fatty acid; WT, wild type.