Table 2.

Recent lipid nanoparticle delivery systems for mRNA-based vaccines.

Indication	Nanodelivery System Compositions	Route of Administration	In Vivo Model
Influenza virus	Ionizable lipid, DSPC, cholesterol, PEG lipid	Intramuscular	Rodents and NHPs
Influenza virus	DOTAP, DOPE, (DSPE-Mpeg2000), Mannose	Intranasal	Mice
COVID-19	Ionizable lipid, DSPC, cholesterol, PEG lipid	Intramuscular	Mice and NHPs
Respiratory syncytial virus	Ionizable lipid, DSPC, cholesterol, PEG lipid	Intramuscular	Mice and cotton rats

NHPs; non-human primates.