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The whole-body plethysmography indicates severe lung dysfunction in the P.1-infected mice. The evaluation of lung function for respiratory frequency (A), enhanced pause (Penh) (B), and exhalatory flow curve (Rpef) (C) in the Wt strain and the P.1 and Delta-infected K18-hACE mice. A multiple t test was applied, using GraphPad Prism 8.0; p < 0.05, was considered significant (** p ≤ 0.005 and **** p ≤ 0.0001).
