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. Author manuscript; available in PMC: 2023 Apr 28.
Published in final edited form as: Annu Rev Biomed Data Sci. 2021 May 11;4:227–253. doi: 10.1146/annurev-biodatasci-092820-112713

Figure 4.

Figure 4

Multiple independent factors influence the potential of a neopeptide to create an effective neoepitope. A mutation with high clonality and robust expression, with the potential to be presented by multiple HLA alleles, may still be ineffective if the MHC alleles to which it can bind are somatically altered or only weakly expressed. Loss of MHC integrity is indicated by faded color. In this way, the landscape of potentially immunogenic neoepitopes may be considerably smaller than what might be predicted based on HLA affinities for neopeptides. Figure adapted from images created with BioRender.com. Abbreviations: HLA, human leukocyte antigen; LOH, loss of heterozygosity; MHC, major histocompatibility complex; MHC-I, MHC class I; pMHC, peptide–MHC.