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. Author manuscript; available in PMC: 2023 Apr 28.
Published in final edited form as: Annu Rev Biomed Data Sci. 2021 May 11;4:227–253. doi: 10.1146/annurev-biodatasci-092820-112713

Figure 5.

Figure 5

Workflow for in silico mapping of the somatic landscape of tumors to putative immunogenic neoantigens for clinical applications. Blue text indicates steps that are less commonly performed. References for further reading are included in parentheses. Abbreviations: aa, amino acids; HLA, human leukocyte antigen; LOH, loss of heterozygosity; MHC, major histocompatibility complex; MHC-I, MHC class I; MHC-II, MHC class II; uORF, upstream open reading frame.