Figure 3.

The treatment with NAC as an adjuvant therapy may contribute to reducing the OS associated with SARS-CoV-2 infection through GSH generation, which favors the increase in the enzymes that employed this antioxidant molecule. Abbreviations: Cu = copper, GCL = glutamate cysteine ligase, GPx = glutathione peroxidase, GR = glutathione reductase, GSH = glutathione, GSSG = oxidized glutathione, GS T= glutathione-S-transferase, H₂ O₂ = hydrogen peroxide, LPO = lipoperoxidation, Mn = manganese, MOF = multiple organ failure, NAC = N-acetylcysteine, O₂^– = superoxide anion, OH = hydroxyl, OS = oxidative stress, SOD = superoxide dismutase, TAC = total antioxidant capacity, TrxR = thioredoxin reductase, Zn = zinc.