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. 2023 Apr 26;7(5):e0114. doi: 10.1097/HC9.0000000000000114

FIGURE 1.

FIGURE 1

The macrophage-inducible C-type lectin ligand, β-GluCer, was increased in the circulation of patients with AH and mice after exposure to Gao-binge EtOH feeding. (A) Concentration of β-GluCer (d18:1/16:0) in serum of HCs (n=8) and patients with moderate AH (n=6), severe AH (n=9), or alcohol-associated cirrhosis (n=9). (B) Concentration of β-GluCer was correlated with MELD scores of patients with moderate and severe AH. (C) Concentration of β-GluCer in plasma of mice after Gao-binge EtOH feeding. (D) β-GluCer in culture medium of primary hepatocytes treated with 150 mM EtOH for 24hrs. β-GluCer concentrations were measured by mass spectroscopy. Data represent mean±SEM. ANOVA (A) or 2-tailed unpaired Student t test (C, D). *p < 0.05, **p < 0.01, ****p < 0.0001. Abbreviations: AH, alcohol-associated hepatitis; β-GluCer, β-glucosylceramide; EtOH, ethanol; MELD, model for end-stage liver disease.