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. 2023 Apr 13;19(4):e1011305. doi: 10.1371/journal.ppat.1011305

Fig 7. Working model for the regulation of NS mRNA splicing.

Fig 7

NEP mRNA is a spliced form of NS1 mRNA. The splicing complex binds (scissors) to the 3’ splicing site of NS1 mRNA and regulates alternative splicing. YTHDC1 binds to the m6A modification site on the 3’ splice site and inhibits the splicing process. The A530C mutation results in reduced binding of NS mRNA by YTHDC1, which promotes NS1 mRNA splicing and produces more NEP, thereby inhibiting viral polymerase activity.