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. 2023 Apr 13;15(4):958. doi: 10.3390/v15040958

Table 1.

Table 1 shows the location of known tick-borne encephalitis virus (TBEV) or Powassan virus (POWV) T cell epitopes in murine or human infection.

Virus Organism Epitope Amino acid Sequence MHC Restriction Virus Reported Refs. Notes
TBEV Human NS31984-1992 ILLDNITTL HLA-A2 TBE EK-328 (Siberian subtype) [44,52]
Human NS2a1207-1215 MLLQAVFEL HLA-A2 TBEV-Neudoerfl [44] Not conserved among Siberian and Asian strains
Human NS52831-2839 SLINGVVKL HLA-A2 TBEV-Neudoerfl [44]
Human NS53374-3382 NIWGAVEKV HLA-A2 TBEV-Neudoerfl [44]
Human NS32084-2092 RPVWKDARM HLA-B7 TBEV-Neudoerfl [44] Not conserved among Siberian and Asian strains
Human NS31734-1742 RVRFHSPAV HLA-B7 TBEV-Neudoerfl [44]
Human NS4b2496-2504 LPLGHRLWL HLA-B7 TBEV-Neudoerfl [44]
POWV Murine E282-291 THLENRDFV H2-Db POWV-LB [69]
Murine E351-361 RCPTTGPATL H2-Db or H2-Kb POWV-LB [69]
Murine E525-535 EFGPPHAVKM I-Ab POWV-LB [69]
Murine E631-641 HGVPAVNVAM I-Ab POWV-LB [69]