Table 3.
Available Device Algorithms Designed to Optimize CRT Performance.
| Algorithm | Manufacturer | Optimization | Mode | Programmable? | Dynamic? | Safety Endpoint Met? | Trial Efficacy Endpoint Met? * |
|---|---|---|---|---|---|---|---|
| AdaptivCRT [63] | Medtronic | AV, VV | IEGM | No | Yes (1/min) | Yes | Non-inferior |
| QuickOpt [64] | Abbott | AV, VV | IEGM | Yes | No | Yes | Non-inferior |
| SmartDelay [65] | Boston | AV | IEGM | No | No | Yes | Equivalent |
| SonR [66] | Sorin | AV, VV | Hemodynamic sensor | No | Yes (1/week) | Yes | Non-inferior |
| SyncAV [67] | Abbott | AV | IEGM | Yes | Yes (1/256 beats) | NR | NR |
| AutoAdapt † | Biotronik | AV, VV | IEGM | NR | Yes (1/min) | NR | NR |
IEGM = intracardiac electrograms; NR = Not reported; * Comparison versus conventional BiV pacing without device algorithms programmed on or versus echo-guided CRT optimization; † NCT04774523.