Table 2.
Genetic variation and their relation to cannabinoids response.
| Protein | Gene | Function | Variation | Effect | Ref. |
|---|---|---|---|---|---|
| CB1 | CNR1 | Receptor | 63-9597T > C | Cannabinoids addiction | [54] |
| CB2 | CNR2 | Receptor | 946C > T | The effect and the main function of the CB2 receptor are altered | [54] |
| FAAH protein | Fatty Acid Amide Hydrolase FAAH |
Biotransformation | 385C > A | It is associated with drug abuse | [55] |
| Catechol-O-methyltransferase enzyme | COMT | The regulation and inactivation of catecholamine neurotransmitters in the brain | 472A > G | Modest controllable effect of cannabinoids consumption on executive functions | [56] |
| GABA | GABRA2 | Receptor | 231A > G | No significant effect on the drug dependence | [57] |
| Mu opioid receptor | OPRM1 | Receptor | 118A > G | No significant effect | [58] |
| ErbB3, ErbB4 | NRG1 | Promotes the growth, differentiation, and survival of a wide range of cell types | 122-16329C > T | Associated with cannabinoids dependence | [59] |