Table 3.

Various alleles and their relation to the metabolizing enzyme activity.

Gene	Allele	Nucleotide Change	Effect	Ref.
CYP2D6	CYP2D6*3	A2549del	It will produce a protein with little or no function, which means increased activity of cannabinoids in the body.	[73]
CYP2D6	CYP2D6*4	G1846A	The activity of the enzyme is reduced, causing drug accumulation in the body.	[73]
CYP2C9	CYP2C9*2	c.430C > T	The activity of the enzyme is reduced, causing drug accumulation in the body.	[74]
CYP2C9	CYP2C9*3	c.1075A	The activity of the enzyme is reduced, causing drug accumulation in the body.	[74]
CYP3A4	CYP3A4*2	664 T-C	The activity of the enzyme is reduced, causing an increase in the drug’s half-life time.	[74]
CYP3A4	CYP3A4*11	1088 C-T	The activity of the enzyme is reduced, causing an increase in the drug’s half-life time.	[75]
CYP3A4	CYP3A4*12	1117 C-T	The activity of the enzyme is reduced, causing an increase in the drug’s half-life time.	[76]
CYP3A4	CYP3A4*17	566 T-C	Decrease in the enzyme activity, which increases the half-life of the drug.	[69]
UGT1A	UGT1A9*3a	98T-C	Reduction or inactivation of the enzyme.	[77]
UGT1A	UGT1A9*4	726 T-G	Reduction or inactivation of the enzyme.	[78]
UGT1A	UGT1A9* 5	766 G-A	Reduction or inactivation of the enzyme.	[79]
UGT1A	UGT1A1*3	1124 C-T	It will lead to the inactivation of the enzyme.	[80]
UGT1A	UGT1A1*10	1021C-T	Dimension in the enzyme activity.	[81]
UGT1A	UGT1A1*13	508-510del	Inactivation of the enzyme.	[82]