Figure 2.
Role of (atrial) cardiomyocyte RGS4 in the context of human AFib. Note that the free Gi/o-protein-derived Gβγ dimer can also activate certain isoforms of PLCβ directly. Also depicted is the inhibitory effect of RGS4 on NLRP3 inflammasome (indirectly, via enhanced PKA-dependent phosphorylation) which awaits experimental confirmation. AngII: angiotensin II; ACh: acetylcholine; IP3: inositol 1′, 4′, 5′-trisphosphate; Pi: inorganic phosphate; ASC: apoptosis-associated speck-like protein containing a caspase recruitment domain (CARD); Pro-Casp-1: pro-caspase-1; HR: heart rate. See text for details and all other molecular acronym descriptions.