Table 1.

Summary of the most important documented effects of cardiac RGS proteins.

RGS Isoform	Effects in the Heart
RGS3	↓ Cardiac hypertrophy/remodeling in response to PO; ↑ Cardiac function in response to PO
RGS4	↓ Cardiac hypertrophy/remodeling in response to PO; ↓ Cardiac arrhythmogenesis/AFib risk; ↓ Cardiac inflammation/adverse remodeling; ↓ NE release from SNS neurons
RGS16	↑ Cardio-protection against LPS/sepsis
RGS2; RGS4; RGS6	HR regulation

PO: pressure overload; LPS: lipopolysaccharide; NE: norepinephrine; SNS: sympathetic nervous system; HR: heart rate; AFib: atrial fibrillation.