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. 2023 Apr 20;62(5):65. doi: 10.3892/ijo.2023.5513

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Copyright: © Tian et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Several signaling pathways are closely related to NEDD8. L11 is modified by NEDD8 and remains in the nucleolus; in contrast, unmodified L11 enters the nucleoplasm to bind to MDM2, thereby promoting the transcriptional activation of p53. IκB, the inhibitor of NF-κB, is recognized by NEDD8-modified SCF after phosphorylation, thereby degrading it and activating the NF-κB signaling pathway. In the PI3K/AKT/mTOR signaling pathway, PTEN is modified by NEDD8 and moves into the nucleus, promoting the phosphorylation of PIP2 and activating downstream pathways. NEDD8, neural precursor cell expressed developmentally downregulated 8; PTEN, phosphatase and tensin homolog; CSN, constitutive photomorphogenesis signalosome; MDM2, murine double minute 2; SCF, Skp1-CUL1-F-box protein; PI3K, phosphatidylinositol-3-kinase; AKT, protein kinase B; mTOR, mammalian target of rapamycin; PDK1, phosphoinositide-dependent kinase 1; RBX, ring-box; NEDP1, NEDD8 protease 1.