Fig. 5.

Effect of the S protein on HDL capacity to remove lipids and mediate the efflux of cholesterol on HDL samples from individuals with low triglycerides/high cholesterol (LTHC), low triglycerides/low cholesterol (LTLC), and high triglycerides/high cholesterol (HTHC) plasma levels. (A) lipid removal by NR. (B) cholesterol efflux capacity. The lipid donor for NR was d-DMPC: d-cholesterol 80:20 mol%. The data represent the means ± SE. of at least three independent measurements, errors are derived from Bayesian MCMC analysis. Levels of significance were determined by unpaired two-tailed Student's t-test. Significant differences were considered at ∗ p < 0.05, ∗∗p < 0.01, and ***p < 0.001 compared to HDL LTHC¹, HDL LTLC^2, and HDL HTHC³. The NR profiles and best fits are given in Supporting Information Figure S6.