Table 1:
Maternal and neonatal clinical characteristics of the study cohort
| All Subjects (n=28) | Infants born SGA (n=15) | Infants born AGA (n=13) | P-value* | |
|---|---|---|---|---|
| Maternal Characteristics | ||||
| Maternal Age (years) | 28.57 ± 7.11 | 28.67 ± 8.28 | 28.46 ± 5.81 | 0.94 |
| Maternal Gravida | 2.74 ± 2.68 | 1.80 ± 1.37 | 3.92 ± 3.45 | 0.04 |
| Maternal Parity | 0.74 ± 1.23 | 0.27 ± 0.59 | 1.33 ± 1.56 | 0.02 |
| Maternal HDP, n (%) | 10 (36%) | 5 (33%) | 5 (38%) | 0.99 |
| Preterm labor, n (%) | 6 (21%) | 3 (20%) | 3 (23%) | 0.99 |
| Vaginal delivery, n (%) | 18 (64%) | 11 (73%) | 7 (54%) | 0.76 |
| Fetal Characteristics & Brain Volumes | ||||
| GA at Fetal Study (weeks) | 33.35 ± 3.67 | 33.97 ± 3.28 | 32.65 ± 4.10 | 0.35 |
| Placental (cm3) | 525 ± 159 | 480 ± 129 | 575 ± 180 | 0.13 |
| Total brain (cm3) | 201 ± 61 | 208 ± 53 | 193 ± 70 | 0.51 |
| Cerebral (cm3) | 195 ± 59 | 203 ± 53 | 185 ± 67 | 0.43 |
| Cortical grey matter (cm3) | 75 ± 20 | 78 ± 19 | 73 ± 22 | 0.61 |
| Cerebral white matter (cm3) | 102 ± 21 | 104 ± 17 | 100 ± 24 | 0.64 |
| Sub-cortical grey matter (cm3) | 18.3 ± 3.8 | 18.9 ± 3.4 | 17.6 ± 4.1 | 0.41 |
| Cerebellum (cm3) | 9.8 ± 3.8 | 9.9 ± 3.4 | 9.7 ± 4.4 | 0.87 |
| Brainstem (cm3) | 4.3 ± 1.1 | 4.7 ± 0.9 | 4.2 ± 1.3 | 0.54 |
| Infant Characteristics | ||||
| Infant Male Sex (n, %) | 8 (27%) | 5 (46%) | 3 (23%) | 0.43 |
| GA at Birth (weeks) 1 | 37.22 ± 2.68 (38, 37–39) | 37.07 ± 2.71 (37, 37–39) | 37.42 ± 2.75 (38, 36–39) | 0.74 |
| Birth Weight (grams) 2 | 2312 ± 576 (2307, 1957–2786) |
2121 ± 512 (2210, 1835–2440) |
2580 ± 572 (2786, 2000–2825) |
0.04 |
| Birth Weight (%)2 | 9.15 ± 10.46 (6.5, 1–12) | 2.80 ± 2.78 (2, 0–5) | 17.82 ± 10.93 (14, 12–19) | <0.01 |
| Birth Length (cm) 2 | 45.25 ± 4.50 (45.5, 43.8–48.8) | 44.81 ± 3.44 (45, 44.3–46) | 45.77 ± 5.64 (48.5, 43.5–50) | 0.61 |
| Birth Length (%)2 | 21.79 ± 18.00 (19, 6.5–33) | 12.69 ± 11.24 (11, 3.5–20) | 32.55 ± 18.96 (27, 18–50) | <0.01 |
| Head Circumference (cm) 2 | 30.92 ± 6.38 (31.5, 30.3–33) | 30.63 ± 2.51 (31, 29.8–32.5) | 33.54 ± 4.50 (32.5, 31–34.25) | 0.06 |
| Head Circumference (%)2 | 22.88 ± 25.59 (16.5, 1.5–36) | 10.08 ± 12.52 (3, 1–16.5) | 38.00 ± 29.22 (30, 20–54) | <0.01 |
| CGA at NNNS | 41.37 ± 2.12 | 41.29 ± 2.30 | 41.46 ± 1.98 | 0.84 |
Abbreviations: GA – gestational age; SGA – small for gestational age, AGA – appropriate for gestational age, HDP - hypertensive disorder of pregnancy, CGA – corrected gestational age. NNNS - NICU Network Neurobehavioral Scale;
1
Numbers in parentheses represent (median, 25th-75th percentile);
2
Data available for 29 (91%) of infants