Table 4:

Association between placental, global and regional fetal brain volumes with NNNS scores

NNNS Domain	Placental Volume		Total Brain Volume		Cerebral Volume		Cerebellar Volume		Brainstem Volume
	β*	p-value	β*	p-value	β*	p-value	β*	p-value	β*	p-value
Attention1	−0.002	0.883	0.011	0.231	0.018	0.110	0.396	0.007	0.471	0.356
Arousal	−0.010	0.248	−0.078	0.211	−0.011	0.146	−0.140	0.105	−0.231	0.541
Self-regulation	0.004	<.0001	0.013	0.035	0.010	0.304	0.136	0.184	0.892	0.000 **
Handling	−0.001	0.285	−0.001	0.706	−0.001	0.861	−0.065	0.006	−0.109	0.236
Quality of movement	0.001	0.281	0.007	0.112	0.005	0.387	0.017	0.828	0.229	0.377
Excitability	−0.010	0.014	−0.027	0.309	−0.024	0.467	−0.473	0.161	−1.807	0.137
Lethargy	−0.002	0.417	−0.012	0.173	0.009	0.502	−0.321	0.031	−1.250	0.046
Non-optimal reflexes	−0.037	0.084	0.002	0.938	0.036	0.230	−0.671	0.001	−1.627	0.044
Hypertonicity	0.000	0.943	−0.000	0.946	0.000	0.969	0.004	0.950	0.110	0.548
Hypotonicity	−0.001	0.146	0.008	0.050	0.012	0.012	0.064	0.315	0.052	0.831
Stress-Abstinence	0.000	0.936	0.000	0.909	−0.000	0.069	0.005	0.334	0.014	0.409

Abbreviations: NNNS – NICU Network Neurobehavioral Scale

^*Based on GEE models, accounting for gestational age at scan at fetal sex

¹20 infants in correct state to assess attention; Notes: Habituation and asymmetric reflexes excluded given low numbers; highlighted cell denotes p<0.05;

^**denotes statistically significance following adjustment for multiple comparisons (q=0.001)