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. 2023 Mar 3;128(10):1828–1837. doi: 10.1038/s41416-023-02202-4

Fig. 4. ZNF683+ Trm cells enhance tumour suppression through positive feedback by autocrine IFN-γ.

Fig. 4

a Distribution of CD8A +, ITGAE + and ZNF683+ cells in the t-SNE plot. b GSEA comparing ZNF683+ and ZNF683– Trm cell clusters. c Violin plot showing the expression of cytotoxic cytokines and immune checkpoint molecules in association with ZNF683 expression. d The hypothesis of signals surrounding ZNF683. e TBX21–ZNF683 expression ratio in Trm cells. f t-SNE plot of cells expressing ZNF683 and TBX21 (red, ZNF683; blue, TBX21). g High ITGAE and high-CD8A cases with high expression of ZNF683 in the TCGA database; TOP4 signalling was elevated in GSEA was IFN-γ and TCR signalling. ZNF683 zinc finger protein 683, Trm cells tissue-resident memory T cells, IFN-γ interferon-gamma, t-SNE t-distributed stochastic neighbour embedding, GSEA gene set enrichment analysis, TCGA The Cancer Genome Atlas, ITGAE integrin subunit alpha E, TCR T-cell receptor.