Table 2.
Univariate Cox regression analysis of the associations of CD44 expression with patient survival.
| Cancer | OS | PFI | DFI | DSS | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| HR | HR (95%CI) | P-value | HR | HR (95%CI) | P-value | HR | HR (95%CI) | P-value | HR | HR (95%CI) | P-value | |
| ACC | 0.964 | (0.705–1.320) | 0.821 | 0.874 | (0.675–1.130) | 0.303 | 0.977 | (0.605–1.579) | 0.925 | 0.889 | (0.635–1.244) | 0.492 |
| BLCA | 1.065 | (0.966–1.173) | 0.205 | 1.044 | (0.945–1.153) | 0.401 | 0.955 | (0.756–1.206) | 0.697 | 1.134 | (1.004–1.281) | 0.043 |
| BRCA | 0.924 | (0.788–1.082) | 0.324 | 0.817 | (0.697–0.959) | 0.013 | 0.798 | (0.645–0.988) | 0.038 | 0.700 | (0.568–0.864) | < 0.001 |
| CESC | 1.069 | (0.857–1.333) | 0.555 | 1.005 | (0.807–1.251) | 0.965 | 0.782 | (0.547–1.118) | 0.177 | 1.012 | (0.788–1.300) | 0.924 |
| CHOL | 0.907 | (0.668–1.232) | 0.532 | 0.794 | (0.598–1.055) | 0.112 | 1.060 | (0.731–1.538) | 0.759 | 0.903 | (0.652–1.249) | 0.537 |
| COAD | 0.993 | (0.736–1.339) | 0.961 | 0.929 | (0.701–1.232) | 0.610 | 0.859 | (0.467–1.577) | 0.623 | 0.984 | (0.673–1.439) | 0.934 |
| DLBC | 0.800 | (0.359–1.779) | 0.584 | 0.795 | (0.396–1.596) | 0.519 | 0.950 | (0.174–5.200) | 0.953 | 1.068 | (0.357–3.200) | 0.906 |
| ESCA | 0.969 | (0.765–1.226) | 0.791 | 1.080 | (0.876–1.331) | 0.470 | 1.363 | (0.912–2.039) | 0.131 | 1.019 | (0.772–1.344) | 0.895 |
| GBM | 1.169 | (0.990–1.380) | 0.065 | 1.253 | (1.054–1.489) | 0.010 | / | / | / | 1.157 | (0.965–1.386) | 0.114 |
| HNSC | 1.176 | (0.977–1.415) | 0.086 | 1.236 | (1.014–1.508) | 0.036 | 1.191 | (0.681–2.083) | 0.539 | 1.321 | (1.023–1.707) | 0.033 |
| KICH | 1.051 | (0.638–1.732) | 0.844 | 1.050 | (0.668–1.652) | 0.831 | 0.772 | (0.340–1.751) | 0.535 | 1.136 | (0.640–2.019) | 0.663 |
| KIRC | 1.476 | (1.269–1.718) | < 0.001 | 1.384 | (1.182–1.620) | < 0.001 | 0.827 | (0.485–1.411) | 0.486 | 1.690 | (1.408–2.030) | < 0.001 |
| KIRP | 1.289 | (1.029–1.615) | 0.027 | 1.112 | (0.905–1.367) | 0.312 | 1.073 | (0.785–1.467) | 0.657 | 1.363 | (1.044–1.779) | 0.023 |
| LAML | 0.779 | (0.595–1.019) | 0.068 | / | / | / | / | / | / | / | / | / |
| LGG | 1.416 | (1.232–1.627) | < 0.001 | 1.318 | (1.178–1.473) | < 0.001 | 1.223 | (0.881–1.697) | 0.229 | 1.481 | (1.273–1.723) | < 0.001 |
| LIHC | 1.131 | (0.984–1.300) | 0.083 | 1.006 | (0.891–1.136) | 0.924 | 0.960 | (0.834–1.105) | 0.572 | 1.094 | (0.908–1.319) | 0.345 |
| LUAD | 1.021 | (0.881–1.183) | 0.782 | 1.004 | (0.872–1.157) | 0.952 | 1.011 | (0.817–1.250) | 0.923 | 1.006 | (0.830–1.219) | 0.953 |
| LUSC | 0.928 | (0.796–1.083) | 0.345 | 0.938 | (0.778–1.133) | 0.508 | 0.947 | (0.706–1.269) | 0.714 | 0.822 | (0.653–1.034) | 0.094 |
| MESO | 1.305 | (1.033–1.649) | 0.025 | 1.094 | (0.863–1.386) | 0.457 | 1.286 | (0.700–2.361) | 0.417 | 1.227 | (0.919–1.639) | 0.166 |
| OV | 0.895 | (0.777–1.031) | 0.125 | 0.882 | (0.776–1.002) | 0.054 | 0.817 | (0.675–0.989) | 0.038 | 0.869 | (0.745–1.013) | 0.073 |
| PAAD | 1.650 | (1.245–2.188) | < 0.001 | 1.665 | (1.257–2.206) | < 0.001 | 2.882 | (1.508–5.505) | 0.001 | 1.574 | (1.154–2.147) | 0.004 |
| PCPG | 0.780 | (0.495–1.227) | 0.282 | 0.723 | (0.546–0.958) | 0.024 | 0.716 | (0.365–1.404) | 0.331 | 0.742 | (0.449–1.227) | 0.245 |
| PRAD | 0.890 | (0.504–1.572) | 0.688 | 0.805 | (0.655–0.991) | 0.041 | 0.837 | (0.575–1.218) | 0.353 | 0.592 | (0.272–1.285) | 0.185 |
| READ | 0.628 | (0.334–1.179) | 0.147 | 0.843 | (0.477–1.492) | 0.559 | 0.682 | (0.107–4.347) | 0.685 | 1.047 | (0.387–2.832) | 0.928 |
| SARC | 0.828 | (0.707–0.970) | 0.019 | 0.943 | (0.823–1.080) | 0.394 | 0.961 | (0.784–1.178) | 0.702 | 0.801 | (0.674–0.952) | 0.012 |
| SKCM | 0.936 | (0.827–1.059) | 0.295 | 0.939 | (0.844–1.045) | 0.252 | / | / | / | 0.938 | (0.820–1.073) | 0.353 |
| STAD | 1.129 | (0.978–1.304) | 0.097 | 1.157 | (0.992–1.348) | 0.063 | 1.109 | (0.836–1.472) | 0.474 | 1.181 | (0.986–1.413) | 0.070 |
| TGCT | 2.256 | (0.922–5.523) | 0.075 | 0.926 | (0.679–1.262) | 0.626 | 0.871 | (0.605–1.253) | 0.457 | 2.226 | (0.901–5.501) | 0.083 |
| THCA | 0.724 | (0.386–1.358) | 0.314 | 1.122 | (0.767–1.641) | 0.552 | 1.343 | (0.785–2.295) | 0.282 | 0.492 | (0.217–1.114) | 0.089 |
| THYM | 1.674 | (0.814–3.441) | 0.161 | 1.697 | (1.033–2.788) | 0.037 | / | / | / | 1.157 | (0.381–3.519) | 0.797 |
| UCEC | 0.887 | (0.740–1.062) | 0.193 | 0.831 | (0.711–0.972) | 0.020 | 0.830 | (0.662–1.042) | 0.108 | 0.785 | (0.628–0.981) | 0.033 |
| UCS | 0.903 | (0.646–1.262) | 0.55 | 0.950 | (0.701–1.289) | 0.742 | 0.923 | (0.500–1.705) | 0.798 | 0.834 | (0.578–1.203) | 0.331 |
| UVM | 0.305 | (0.143–0.650) | 0.002 | 0.392 | (0.194–0.794) | 0.009 | / | / | / | 0.294 | (0.136–0.637) | 0.002 |
OS overall survival, PFI progression-free interval, DFI disease-free interval, DSS disease-specific survival.