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. 2023 Apr 28;13:6999. doi: 10.1038/s41598-023-33803-x

Table 1.

Results of univariate analysis of indicated variables in patients with SSNs.

Pre-invasive/minimally invasive (n = 473) (% or range) Invasive (n = 337) (% or range) p
Age 51.92 ± 11.79 59.55 ± 9.34  < 0.001
Gender 0.002
 Male 144 (30.4) 138 (40.9)
 Female 329 (69.6) 199 (59.1)
Location 0.176
 LLL 67 (14.2) 30 (8.9)
 LUL 132 (27.9) 97 (28.8)
 RLL 57 (12.1) 52 (15.4)
 RML 35 (7.4) 26 (7.7)
 RUL 182 (38.5) 132 (39.2)
Tumor size (mm) 9.00 (7.16–11.05) 17.18 (13.00–22.22)  < 0.001
Mean CT value (HU) − 585.94 (− 666.50 to − 491.92) − 421.79 (− 532.50 to − 285.75)  < 0.001
Size of solid component (mm) 3.40 (2.56–4.40) 8.30 (6.42–11.51)  < 0.001
Mean CT value of solid component (HU) − 328.73 (− 413.50 to − 229.43) − 158.00 (− 261.03 to − 78.67)  < 0.001
C/T ratio 0.34 (0.26–0.41) 0.50 (0.40–0.65)  < 0.001
Pattern  < 0.001
 pGGN 304 (64.3) 64 (19.0)
 PSN 169 (35.7) 273 (81.0)
 Bubble-like sign 70 (14.8) 74 (22.0) 0.009
 Air bronchogram 56 (11.8) 91 (27.0)  < 0.001
Margin  < 0.001
 Smooth 340 (71.9) 50 (14.8)
 Lobular 71 (15.0) 99 (29.4)
 Spiculated 43 (9.1) 84 (24.9)
 Lobular + spiculated 19 (4.0) 104 (30.9)
Operation type  < 0.001
 Segmentectomy 196 (41.4) 32 (9.5)
 Partial resection 105 (22.2) 64 (19.0)
 Lobectomy 172 (36.4) 241 (71.5)

C/T ratio ratio of solid component to the whole tumor.