Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2023 Apr 28;14:2445. doi: 10.1038/s41467-023-38134-z

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

PMC Copyright notice

Fig. 1 — a Scheme of the experimental set up. Mice are irradiated with a dose of 10 Gy or 17 Gy and monitored by CT-scan to follow the development of pulmonary fibrosis. Mice are sacrificed at 1, 2, 3, 4, and 5 months after IR, and lungs are enzymatically and mechanically dissociated into a single cell suspension before being loaded in the 10x Chromium Controller System (image provided by 10x Genomics). b UMAP visualization of 102,869 cells from 20 different samples (5 NI; 5 IR_10Gy, one per time point; 10 IR_17Gy, two per time point) annotated by cell type. c Dot plot of the expression of the markers used for cell type identification. d Dynamics in cell proportions of the endothelial, mesenchymal, epithelial, lymphoid, and myeloid cells across the NI and IR conditions at the different time points and doses.