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. 2023 Apr 28;9:138. doi: 10.1038/s41420-023-01437-7

Fig. 1. Senescence is linked to diabetic wounds.

Fig. 1

a A hypothesized model of the impact of NCOA4 deficiency in senescent fibroblasts within diabetic wounds. b Representative H & E staining and immunostaining of p16 photomicrographs illustrating the architecture of diabetes wounds (DW) and normal skin (NS). Scale bar = 200 μm. c Quantification of p16 immunostaining in b. d The mRNA level of p16 were detected by real-time PCR in normal glucose cultured fibroblasts (NG) and high glucose cultured fibroblasts (SF). e SA-β-GAL staining illustrates increased senescent fibroblasts after high glucose culture. Scale bar = 100 μm. Data represent the mean ± SEM of triplicates. *P < 0.05; ****P < 0.0001.