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. 2023 Mar 13;199(1):13–23. doi: 10.1007/s10549-023-06895-2

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© The Author(s) 2023

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Antitumor activity and PD of MEN1611 and combination in the JIMT-1 cell-derived xenograft tumor model. Tumor cells were injected s.c. into CD-1 nude mice at day 0 and drug dosing started on day 15. Black line and red arrows represent MEN1611 and trastuzumab dosing respectively. a Tumor volume and statistical analysis of vehicle and treated groups according to the Mann Whitney test, evaluated at day 50. JIMT-1 cell-derived xenograft breast cancer model was treated with MEN1611 given p.o. once-daily (QD) at 3.25 mg/Kg versus twice-daily (BID) at 1.6 mg/Kg. At the indicated time points the group of mice (3 mice/group) were sacrificed and tissues were collected. Each tumor mass was dissociated in RIPA buffer and analyzed by capillary immunoassay for pAKT S473, AKT, pS6 S240-244 and S6. b The level of phospho-protein were normalized to total protein and expressed as percentage of the control (c) Lane view for pAKT and total AKT (d)