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. 2023 Apr 11;18(4):1030–1047. doi: 10.1016/j.stemcr.2023.03.006

Figure 4.

Figure 4

Molecular comparison of hPSC-derived nociceptors (WA09/H9) and human DRG samples

(A) PCA of differentiating cells harvested at different timepoints and DRG samples (normal and chronic pain patient).

(B and C) Venn diagrams comparing expressed ion channels in nociceptors (days 28 and 56) and DRG samples.

(D and E) Heatmap comparison of ligand- and voltage-gated ion channels expressed by in vitro-generated nociceptors and DRGs (n = 3). See Figure S5 for detailed analysis of other gene families. Data shown are from three different wells of one representative experiment.