Skip to main content
. Author manuscript; available in PMC: 2024 Oct 1.
Published in final edited form as: Transl Stroke Res. 2022 Oct 29;14(5):704–722. doi: 10.1007/s12975-022-01092-7

Figure 2. Deferoxamine (DFX) treatment at the time of hemorrhage prevents region-specific ventricular expansion after neonatal intra-ventricular hemorrhage (IVH).

Figure 2.

(A) Representative T2-weighted MRI images showing the lateral ventricles (LV), 3rd ventricle (3V), cerebral aqueduct (AQ), and 4th ventricle (4V) 72 h post-intraventricular injection of artificial CSF (aCSF), hemoglobin (HB), HB + DFX, or DFX in post-natal day 4 rats. Scalebars = 1 mm. (B) 3D reconstructions of the ventricular system (LV red, 3V green, 4V blue) 72 h post-injection in the axial, sagittal, and coronal planes. (C–H) Quantification of LV (C), cavum septum pellucidum (CSP) (D), cortex (E), LV/cortex ratio (F), 3V (G), and 4V (H) volumes 72 h post-injection. HB injection resulted in significant increases in LV, CSP, and 3V volumes, as well as an increase in the LV/cortex ratio, but no significant differences in cortex or 4V volumes. DFX treatment at the time of IVH induction resulted in significantly smaller LV and CSP volumes compared to rats injected with HB only. Data are mean ± SEM, n = 9–10 per group; one-way ANOVA with post-hoc Tukey test. (I–J) The rate of hydrocephalus in HB + DFX-injected rats (0 of 8) was significantly lower than the rate of hydrocephalus in HB animals (10 of 18) 11 days post-injection at P15. scalebar = 1 mm. p = 0.0095, Fisher’s exact test