Table 2.
Microbiologic etiology comparative analyses between the two predefined regions and two periods of overall cohort
| Total N = 4195 | NCE N = 2082 | SE N = 2113 | p-Value | Early period (2000–2006) N = 2787 | Later period (2008–2012) N = 1408 | p-Value | |
|---|---|---|---|---|---|---|---|
| Staphylococcus aureus (N = 3882) | 1039 (26.8%) | 506 (26.2%) | 533 (27.2%) | 0.59 | 711 (27.2%) | 328 (26.3%) | 0.61 |
| Viridans group Streptoccoci (N = 3882) | 655 (17.4%) | 295 (15.9%) | 360 (18.2%) | 0.16 | 443 (18%) | 212 (16.7%) | 0.39 |
| Coagulase negative Staphylococcus (N = 3882) | 510 (13.6%) | 219 (10.8%) | 291 (14.9%) | < 0.01 | 327 (12.5%) | 183 (14.8%) | 0.09 |
| Enterococcus spp. (N = 3882) | 427 (10.5%) | 202 (10.1%) | 225 (10.8%) | 0.60 | 269 (8.9%) | 158 (12.5%) | < 0.01 |
| Streptococcus gallolyticus (N = 3882) | 330 (9%) | 173 (12.3%) | 157 (7.3%) | < 0.01 | 221 (8.8%) | 109 (9%) | 0.90 |
| Other streptococcia (N = 3882) | 257 (7.2%) | 143 (10.1%) | 144 (5.8%) | < 0.01 | 159 (6.4%) | 98 (8.1%) | 0.11 |
| Gram negative (not HACEKb) (N = 3882) | 132 (4%) | 59 (3.1%) | 73 (3.7%) | 0.37 | 83 (3.2%) | 49 (3.9%) | 0.25 |
| Polymicrobial (N = 3882) | 85 (1.6%) | 59 (2.6%) | 26 (1.2%) | < 0.01 | 44 (0.5%) | 41 (3%) | < 0.01 |
| HACEKb (N = 3882) | 50 (1.2%) | 28 (1.5%) | 22 (1.1%) | 0.46 | 35 (1.3%) | 15 (1.1%) | 0.68 |
| Fungi (N = 3882) | 53 (1.2%) | 22 (1.2%) | 31 (1.2%) | 0.99 | 36 (1.3%) | 17 (1.2%) | 0.96 |
| Negative culture (N = 3882) | 235 (4.9%) | 124 (2.6%) | 111 (5.9%) | < 0.01 | 219 (8%) | 16 (1.1%) | < 0.01 |
| Other (N = 3882) | 109 (2.6%) | 53 (2.5%) | 56 (2.7%) | 0.73 | 78 (3%) | 31 (2.2%) | 0.20 |
aOther Streptococci including Streptococcus pneumoniae, beta hemolytic group Streptococci, etc.
bHACEK group includes Haemophilus species, Aggregatibacter actinomycetemcomitans, Aggregatibacter aphrophilus (formerly Haemophilus aphrophilus and Haemophilus paraphrophilus), Cardiobacterium hominis, Eikenella corrodens, and Kingella species.