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. 2023 Apr 3;32:359–368. doi: 10.1016/j.omtn.2023.03.023

Figure 2.

Figure 2

Biological function of NAT10

NAT10-modified mRNA ac4C enriched in the CDS region increases mRNA stability, and modifies the mRNA wobble site to promote translation efficiency; NAT10 can influence bone remodeling by altering ac4C modification of RUNX2 mRNA or Gremlin mRNA; NAT10-modified OGA mRNA ac4C influenced meiosis by TBL3-ADCY3 to promote oocyte maturation; fatty acid metabolism in cancer cells is modified by NAT10 through modifying ELOVL6, ACSL1, ACSL3, ACSL4, ACADSB, and ACAT1 mRNA ac4C.