Fig. 2.

Association between genetically elevated polyunsaturated fatty acids and risk of colorectal cancer in 58,131 cases and 67,347 controls. Outcome summary data for colorectal cancer were derived from a meta-analysis of the GECCO, CORECT and CCFR studies. Summary data for fatty acid exposures were derived from either the CHARGE consortium or UK Biobank. The Q P value was derived from a Cochran's Q test for heterogeneity in MR results amongst SNPs in the genetic instrument. The P value column represents the P value for association between the PUFA and cancer, derived from inverse-variance weighted linear regression (>1 SNP) or a Wald ratio test (1 SNP). The “No. SNPs” column represents the number of SNPs present in the genetic instrument. The FADS region (proxied by rs174546) was either included (black data points) or excluded (red data points) from the genetic instrument. Individual PUFAs within the omega 3 and omega 6 sections are sorted according to chain length (shorter to longer). Abbreviations: PUFAs, polyunsaturated fatty acids; SD, standard deviation.