Table 3.
Histopathological Imanguli score for defining features of sg-GVHD with score (adapted from 8). Assessment of MSG 103 biopsies that included 100 biopsies from HCT patients and three healthy control biopsies.
| Chisholm & Mason | |||||
|---|---|---|---|---|---|
| Features and points | 0 | 1 | 2 | 3 | 4 |
| 1. Degree of infiltration | None | Slight | Moderate or < one focus/4mm2 | One focus/4mm2 | >One focus/4mm2 |
| n (%) | 9 (8.7) | 27 (26.2) | 19 (18.45) | 19 (18.45) | 29 (28.2) |
| Parenchymal damage | |||||
| Features and points | 0 | 1 | 2 | 3 | |
| 2. Atrophy | None | <33% of area | 33–66% of area | >66% of area | |
| n (%) | 18 (17.5) | 45 (43.7) | 22 (21.3) | 18 (17.5) | |
| 3. Fibrosis | None | <33% of area | 33–66% of area | >66% of area | |
| n (%) | 13 (12.6) | 45 (43.7) | 31 (30.1) | 14 (13.6) | |
| Total Imanguli points: 10 (Severity score 0 – 0-2 points; Severity score 1 – 3-6 points; Severity score 2 – 7-10 points) | |||||
| Severity score 0; n = 13 (12.6%) Median pathology points: 1 |
Severity score 1; n = 57 (55.4%) Median pathology points: 4 |
Severity score 2; n = 33 (32.0%) Median pathology points: 8 |
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