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. 2023 Apr 1;26(5):106552. doi: 10.1016/j.isci.2023.106552

Figure 6.

Figure 6

Ctnnb1 deficiency in UCP1-positive adipocytes improves metabolic performance in 50-week-old mice

(A–C) Body weight (A), tissue weight (B), and percentage of tissue weight (C) of 50-week-old UBKO and control male mice.

(D and E) Glucose tolerance test after 16-h fasting (D) and calculation of area under the curve (AUC) of 10-month-old UBKO and control male mice (E).

(F and G) Insulin tolerance test after 6-h fasting (F) and calculation of AUC (G) of 10-month-old UBKO and control male mice.

(H–J) mRNA levels of thermogenic genes in BAT (H), iWAT (I), and eWAT (J) of 50-week-old UBKO and control male mice.

(K and L) mRNA levels of genes related to inflammation in iWAT (K) and eWAT (L) of 50-week-old UBKO and control male mice. For A–G, n = 25 for the control group, and n = 19 for the UBKO group. For H–L, n = 8 for each group. Data are shown as means ± SEM. ∗p < 0.05, ∗∗p < 0.01, ∗∗∗p < 0.001. See also Figure S6.