Figure 2.

Hepatic inflammation and organ crosstalk. Stress-induced signals from the liver shape metabolic processes and immune cell phenotypes in remote organs and vice versa. (A) NAFLD is associated with a proinflammatory signature of progenitor cells in the bone marrow. (B) Lipid-associated macrophages in visceral adipose tissue that promote liver inflammation. (C) Cardiovascular disease is related to alteration of hepatic lipid metabolism. (D) Intestinal bacterial translocation and endotoxemia promote liver inflammation in NAFLD. LDL, low-density lipoprotein. (Figure was created with BioRender)