Table 1. Characteristics of the Study Population.
| Characteristic | No. (%) | ||
|---|---|---|---|
| All participants (N = 2846) | Chronologic age at blood draw, y | ||
| <20 (n = 690) | ≥20 (n = 2156) | ||
| Sex | |||
| Male | 1509 (53.0) | 358 (51.9) | 1151 (53.4) |
| Female | 1337 (47.0) | 332 (48.1) | 1005 (46.6) |
| Diagnosis | |||
| Leukemia | 927 (32.6) | 204 (29.6) | 727 (33.7) |
| Lymphoma | 512 (18.0) | 25 (3.6) | 487 (22.6) |
| Sarcoma | 358 (12.6) | 67 (9.7) | 291 (13.5) |
| CNS tumors | 383 (13.5) | 141 (20.4) | 242 (11.2) |
| Embryonala | 391 (13.7) | 114 (16.5) | 277 (12.8). |
| Other | 271 (9.5) | 139 (20.1) | 132 (6.1) |
| Treatment | |||
| Anthracycline | 1613 (56.7) | 349 (50.6) | 1264 (58.6) |
| Alkylating agent | 1614 (56.7) | 344 (49.9) | 1270 (58.9) |
| Epipodophyllotoxin | 971 (34.1) | 218 (31.6) | 753 (34.9) |
| Brain RT | 718 (25.2) | 93 (13.5) | 625 (29.0) |
| Chest RT | 574 (20.2) | 60 (8.7) | 514 (23.8) |
| Abdomen RT | 509 (17.9) | 75 (10.9) | 434 (20.1) |
| Pelvis RT | 440 (15.5) | 60 (8.7) | 380 (17.6) |
| CA-defined groups | |||
| Children | 178 (6.3) | 178 (25.8) | NA |
| Adolescents | 512 (18.0) | 512 (74.2) | NA |
| Younger adults | 1285 (45.2) | NA | 1285 (59.6) |
| Middle-aged adults | 749 (26.3) | NA | 749 (34.7) |
| Older adults | 122 (4.3) | NA | 122 (5.7) |
| Age at DNA sampling, median (IQR), y | 29.1 (20.2-37.4) | 12.9 (9.9-16.1) | 32.4 (27.2-40.1) |
| Age at follow-up, median (IQR), y | 30.3 (9.3-41.5) | 9.8 (7.3-17.6) | 34.1 (10.0-42.8) |
Abbreviations: CA, chronologic age; CNS, central nervous system; NA, not applicable; RT, radiotherapy.
a
Include neuroblastoma, germ cell tumor, and Wilms tumor.