Table 1.
Characteristics of hemochromatosis probands with HFE p.C282Y/p.C282Ya
| Characteristic | NAFLD (n = 16) | No NAFLD (n = 50) | Value of p |
|---|---|---|---|
| Age at diagnosis, y (± 1 SD) | 51 ± 13 | 49 ± 15 | 0.6614 |
| Men, % (n) | 56.3 (9) | 44.0 (22) | 0.5659 |
| Mean transferrin saturation, % (± 1 SD) | 77 ± 14 | 83 ± 17 | 0.1626 |
| Median serum ferritin, µg/L (range) | 1118 (259, 2663) | 567 (247, 2385) | 0.0192 |
| HLA-A*03 positivity, % (n) | 75.0 (12) | 82.0 (41) | 0.7187 |
| Elevated ALT/AST, % (n) | 43.8 (7) | 10.0 (5) | 0.0056 |
| Obesity (BMI ≥ 30.0 kg/m2), % (n) | 18.9 (3) | 16.0 (8) | ~ 1.0000 |
| Diabetes, type 2, % (n) | 31.3 (5) | 10.0 (5) | 0.0427 |
| Hypertension, % (n) | 25.0 (4) | 18.0 (9) | 0.7187 |
| Hyperlipidemia, % (n) | 6.3 (1) | 12.0 (6) | 1.0000 |
| Metabolic syndrome, % (n) | 0.0 (0) | 4.0 (2) | ~ 1.0000 |
a All observations were recorded at diagnosis. Blood specimens were collected during mornings without regard to fasting. ALT, alanine aminotransferase; AST, aspartate aminotransferase; BMI, body mass index; HLA, human leukocyte antigen; NAFLD, non-alcoholic fatty liver disease; SD, standard deviation. No proband had hypogonadotropic hypogonadism, cirrhosis, or cardiomyopathy.